Inhibition effectivity of Halimeda macroloba seaweed extract against fish indigenous bacteria for safety fisheries product

Concerns about the potential for residual antibiotics can cause adverse health effects consumers. The use of inappropriate is feared to lead antimicrobial resistance by pathogens. New sources antibacterial be obtained from bioactive compounds seaweed, one which a H. macroloba type. research objective was determine effectiveness seaweed extract inhibition against indigenous bacteria in fish. samples taken waters Pane Island. extraction process carried out maceration method with methanol p.a solvent. secondary metabolites were phytochemical test. Inhibition test Kirby-Bauer agar diffusion through experimental adding DMSO. have metabolite compounds, there are alkaloids and flavonoids function as an inhibitory force bacteria. Different treatment resulted significant effect on Vibrio parahemolitycus value 10.73 mm. Meanwhile, different Aeromonas hydrophyla salmonicida stated no increasing zone diameter. However, it directly proportional diameter, most effective at concentration 100%.